<논문 및 특허 : 2010년-현재 기준>


  • Hong Bin Yoon, Youra Lee, Donghwa Seo, Saeon Kim, Abu B. Siddique, Jae Yeol Lee, Jeewoo Lim, Jungahn Kim*. Michael addition of thiol compounds on ω-maleate poly(ethylene oxide)s: Model study for the "site-specific" modification of proteins. Macromol. Res. 2017.10.25, accepted.

  • Bo-Bae Seo, Hae-Im Chang, Hyuck Choi, Jeong-Tae Koh, Kwi-Dug Yun, Jae Yeol Lee, Soo-Chang Song*. New approach for vertical bone regeneration using in situ gelling and sustained BMP-2 releasing poly (phosphazene) hydrogel system on peri-implant site with critical defect in a canine model. J. Biomed. Mater. Res. Part B  2017.05.23. In press(DOI: 10.1002/jbm.b.33885).

  • A-ra Jo, Hee-Soo Han, Seunghwan Seo, Ji-Sun Shin, Jae Yeol Lee, Hyoung Ja Kim*, Kyung Tae Lee*. Inhibitory effect of N-feruloylserotonin isolated from Carthamus tinctorius on LPS-induced inflammatory mediators via AP-1 and STAT1/3 inactivation in RAW 264.7 macrophages, Bioorg. Med. Chem. Lett. 201727(23), 5245-5251.

  • Insun Park, Ashwini M. Londhe, Ji Woong Lim, Beoung-Geon Park, Seo Yun Jung, Jae Yeol Lee, Sang Min Lim, Kyoung Tai No, Jiyoun Lee, Ae Nim Pae*. Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction. J. Comput. Aided Mol. Des2017, 31(10), 929-941.

  • Ju-Ha Kim, Hee Young Kwon, Dong Hoon Ryu, Min-Ho Nam, Bum Sang Shim, Jin Han Kim, Jae Yeol Lee, Sung-Hoon Kim*Inhibition of CUG-binding protein 1 and activation of caspases are critically involved in piperazine derivative BK10007S induced apoptosis in hepatocellular carcinoma cells. PLoS One 2017.12(10), e0186490.

  • Xu Kang, Jiange Qiu, Qianqian Li, Katherine Bell, Yifeng Du, Da Woon Jung,  Jae Yeol Lee, Jiukuan Hao, Jianxiong Jiang*. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci. Rep. 2017, 7(1), 9459.

  • Jin Han Kim, Hui Rak Jeong, Da Woon Jung, Hong Bin Yoon, Sun Young Kim, Hyoung Ja Kim, Kyung-Tae Lee*, Vinicius M. Gadotti, Junting Huang, Fang-Xiong Zhang, Gerald W. Zamponi*, Jae Yeol Lee*. Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects. Bioorg. Med. Chem. 2017, 25(17), 4656-4664.

  • Byeongyeon Park, Ji Hye Nam, Jin Han Kim, Hyoung Ja Kim, Valentina Onnis, Gianfranco Balboni*, Kyung-Tae Lee, Jeong Ho Park, Marco Catto, Angelo Carotti*, Jae Yeol Lee*3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes Bioorg. Med. Chem. Lett. 2017, 27(5), 1179-1185.

  • Abu B. Siddique, Jin Wook An, Hyun Jun Kim1, Hyeongjong Park, Young Jin Lee, Geon Chang Lee, Ho-Jung Kang, Jae Yeol Lee, Sehoon Kim, Jungahn Kim*. Synthesis of dual stimuli-responsive polymers through atom transfer radical mechanism in aqueous media. Macromol. Res. 2017, 25(1), 70-78.

  • Seunghwan Seo, Kyoung-Goo Lee, Ji-Sun Shin, Eun Kyoung Chung, Jae Yeol Lee, Hyoung Ja Kim*, Kyung-Tae Lee*. 6´-O-Caffeoyldihydrosyringin isolated from Aster glehni suppresses lipopolysaccharide-induced iNOS, COX-2, TNF-α, IL-1β and IL-6 expression via NF-κB and AP-1 inactivation in RAW 264.7 macrophages. Bioorg. Med. Chem. Lett. 2016, 26(19), 4592-4598.

  • Ji Hoon Park, Eun Beul Park, Jae Yeol LeeJi-Young Min*. Identification of novel membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitors with anti-influenza activities in vitro. Biochem. Biophys. Res. Commun. 2016, 469(4), 848-855.

  • Sung Woo Kim, Abu Bakkar Siddique, Jin Wook An, Hyeon Jong Park, Hyun Jun Kim, Ho-Jung Kang, Jae Yeol Lee, Sehoon Kim, Jungahn Kim*. Quantitative ω-amination, ω-azidolysis, and ω-thiolation of poly(ethylene oxide)s through anionic mechanism. Macromol. Res. 2016, 24(2), 188-195.

  • Saïd M’Dahoma, Vinicius M. Gadotti, Fang-Xiong Zhang, Byeongyeon Park, Ji Hye Nam, Valentina Onnis, Gianfranco Balboni*Jae Yeol Lee*, Gerald W. Zamponi*. Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain. Pflugers Arch. - Eur. J. Physiol. 2016, 468(2), 193-199.

  • Joon Seok Byun, Joo Mi Sohn, Dong Gyu Leem, Byeongyeon Park, Ji Hye Nam, Dong Hyun Shin, Ji Sun Shin, Hyoung Ja Kim, Kyung-Tae Lee*Jae Yeol Lee.* In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells. Bioorg. Med. Chem. Lett. 201626(3), 1073-1079.

  • Sera Yang, Youn Kim, Hyeong Cheol Kim, Abu B. Siddique, Gyusaang Youn, Hyun Jun Kim, Hyeon Jong Park, Jae Yeol Lee, Sehoon Kim, Jungahn Kim*Azide-based heterobifunctional poly(ethylene oxide)s: NaN3-initiated “living” polymerization of ethylene oxide and chain end functionalizations. Polym. Chem. 2016. 7. 394-401.

  •  Minju Kim, Sunhoe Lee, Eun Beul Park, Kwang Jong Kim, Hwi Ho Lee, Ji-Sun Shin, Katrin Fischer, Andreas Koeberle, Oliver Werz, Kyung-Tae Lee*, Jae Yeol Lee*.  Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study. Bioorg. Med. Chem. Lett. 2016, 26(1), 94-99.

  • Jae Ho Jin, Eun Beul Park, Kwang Jong Kim, Minju Kim, Sunhoe Lee, Kyung-Tae Lee, Gyongseon Yang, Sooyoung Byun, Nakyung Lee, Junghyun Goo, Joo Hwan No, Dong Joon Choo*, Jae Yeol Lee* In Vitro Evaluation of s-Triazine Derivatives for African Trypanosomiasis. Bull. Korean Chem. Soc. 201536(9), 2383-2386.

  • Min Jeoung Son, Changbae Jin, Yonh Sup Lee, Jae Yeol Lee, Hyoung Ja Kim* Characterization of Caffeoylglucoside Derivatives and Hypouricemic Activity of the Ethyl Acetate Fraction from Aster glehni. Bull. Korean Chem. Soc. 201536(2), 503-512.

  • Sehyeon Cho, Min Ji Choi, Minju Kim, Sunhoe Lee, Jinsung Lee, Seok Joon Lee, Haelim Cho, Kyung-Tae Lee, Jae Yeol LeeThree-dimensional Quantitative Structure-Activity Relationship Study on Anti-cancer Activity of 3,4-Dihydroquinazoline Derivatives Against Human Lung Cancer A549 Cells. J. Mol. Struct. 2015. 1084, 294-301

  • Abu Bakkar Siddique, Youngjun Cho, Yujin Kim, Sung Hoon Bahng, Sung Woo Kim, Jae Yeol Lee, Ho-Jung Kang, Sehoon Kim, You Han Bae,  Jungahn Kim* pH-Sensitive Drug-Conjugates on Water-Soluble Polymer Frameworks  Macromol. Chem. Phys2015, 216(3), 265–276.

  • Seoung Mook Kang, Jinsung Lee, Jae Ho Jin, Minju Kim, Sunhoe Lee, Hwi Ho Lee, Ji-Sun Shin, Kyung-Tae Lee*, Jae Yeol LeeSynthesis and PGE2 Production Inhibition of s-Triazine Derivatives as a Novel Scaffold in RAW 264.7 Macrophage Cells. Bioorg. Med. Chem. Lett. 2014, 24(23), 5418-5422.

  • Gi Hyun Kwon, Sehyeon Cho, Jinsung Lee, Joo Mi Sohn, Joon Seok Byun, Kyung-Tae Lee, Jae Yeol Lee* CoMSIA 3D-QSAR Analysis of 3,4-Dihydroquinazoline Derivatives Against Human Colon Cancer HT-29 Cells. Bull. Korean Chem. Soc. 2014, 35(11), 3181-3187.

  • Ji Eun Lee, Tae Hui Kwon, Su Jin Gu, Duck-Hyung Lee, B. Moon Kim, Jae Yeol Lee, Jae Kyun Lee, Seon Hee Seo, Ae Nim Pae, Gyochang Keum, Yong Seo Cho*, Sun-Joon Min.* Efficient synthesis of mibefradil analogues: an insight into in vitro stability. Org. Biomol. Chem. 201412(30), 5669-5681.

  • Hong-Kun Rim, Sehyeon Cho, Dong-Hyun Shin, Kyung-Sook Chung, Young-Wuk Cho, Jung-Hye Choi, Jae Yeol Lee*, Kyung-Tae Lee.* T-Type Ca2+ Channel Blocker, KYS05090 Induces Autophagy and Apoptosis in A549 Cells through Inhibiting Glucose Uptake. Molecules 2014, 19(7), 9864-9875.

  • Seung-Hoon Bahng, Nan Hyun Kwon, Hyung Cheol Kim, Abu Bakkar Siddique, Ho-Jung Kang, Jae Yeol Lee, Joohoon Kim, Sehoon Kim, Jungahn Kim*. Simple synthesis of water-dispersible and photoactive titanium dioxide nanoparticles using functionalized poly(ethylene oxide)s. Macromol. Res2014, 22(4), 445-456.

  • Kyung Ju Kim, Min Ji Choi, Ji-Sun  Shin, Minju Kim, Hye-Eun Choi, Seoung Mook Kang, Jae Ho Jin, Kyung-Tae Lee,* Jae Yeol Lee.* Biological Evaluation, and Docking Analysis of a Novel Family of 1-Methyl-1H-pyrrole-2,5-diones as Highly Potent and Selective Cyclooxygenase-2 (COX-2) Inhibitors. Bioorg. Med. Chem. Lett. 201424(8)1958-1962.

  • Doo Li Choi, Sun Jeong Jang, Sehyeon Cho, Hye-Eun Choi, Hong-Kun Rim, Kyung-Tae LeeJae Yeol Lee.* Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist. Bioorg. Med. Chem. Lett. 2014, 24(6), 1565-1570.

  • Sun Jeong Jang, Heung Woo Choi, Doo Li Choi, Sehyeon Cho, Hong-Kun Rim, Hye-Eun Choi, Ki-Sun Kim, Minghua Huang, Hyewhon Rhim, Kyung-Tae Lee*, Jae Yeol Lee*In Vitro Cytotoxicity on Human Ovarian Cancer Cells by T-Type Calcium Channel Blockers. Bioorg. Med. Chem. Lett. 2013, 23(14), 6656-6662.

  • Faisal Hayat, Sungjin Cho, Hyewhon Rhim, Ambily Nath Indu Vuswnath, Ae Nim Pae, Jae Yeol Lee, Dong Joon Choo, Hea-Young Park Choo*. Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group. Bioorg. Med. Chem. 2013, 21(17), 5573-5582.

  • Min Ji Choi, Gi Hyun Kwon, Nam Seok Han, Byoung Wook Yoo, Je Hak Kim, Soo Heui Paik, Yong Ha Chi, Jae Yeol Lee*. Development of 3D-QSAR CoMSIA Models for 5-(Biphenyl-2-yl)-1H-tetrazole Derivatives as Angiotensin II Receptor Type 1 (AT1) Antagonists. Bioorg. Med. Chem. Lett2013, 23(16), 4540-4546. 

  • Yong Ha Chi, Joo Han Lee, Je Hak Kim, Hyun Kwang Tan, Sang Lin Kim, Jae Yeol Lee, Hong-Kun Rim, Soo Heui Paik*, Kyung-Tae Lee.Pharmacological Characterization of BR-A-657, a Highly Potent Nonpeptide Angiotensin II Receptor Antagonist. Biol. Pharm. Bull. 2013, 36(7), 1208-1215. 

  • Hye-Eun Choi, Jung-Hye Choi, Jae Yeol Lee, Je Hak Kim, Ji Han Kim, Joon Kwang Lee, Gyu Il Kim, Yong Park, Yong Ha Chi, Soo Heui Paik, Joo Han Lee, Kyung-Tae Lee.* Synthesis and evaluation of nicotinamide derivative as anti-angiogenic agents  Bioorg. Med. Chem. Lett2013, 23(7), 2083-2088. 

  • Jin Yeong Park, Heung Woo Choi, Doo Li Choi, Sun Jeong Jang, Je Hak Kim, Joo Han Lee, Dong Joon Choo, Jungahn Kim, Kyung-Tae Lee, Jae Yeol Lee.*  Evaluation of T-Type Calcium Channel Blockers against Human Pancreatic MIA PaCa-2 Carcinoma Xenografts. Bull. Korean Chem. Soc. 2013, 34(2), 482-488 (Cover Article). 

  • Kijae Lee, Van Chung Pham, Min Ji Choi, Kyung Ju Kim, Jungahn Kim, Dong Joon Choo, Kyung-Tae Lee, Yeon Gyu Yu, Jae Yeol Lee*. Fragment-Based Discovery of Novel and Selective mPGES-1 Inhibitors Part 1: Identification of Sulfonamido-1,2,3-Triazole-4,5-Dicarboxlic Acid. Bioorg. Med. Chem. Lett2013, 23(1), 75-80. 

  • Joo Hyun Nam, Woo Seok Choi, Jae Hyeok Lee, Nan Hyun Kwon, Ho-Jung Kang, Jae Yeol Lee, Sehoon Kim, and Jungahn Kim.* Synthesis of Stimuli-Responsive PEO-Based Triblock Copolymers andTheir Applications for Preparation of Iron Oxide Nanoparticles. Macromol. Res2012, 20(11), 1173-1180.

  • Sung-Jun Park; Seong-Gu Han; Hafiz Muhammad Ahsan; Kijae Lee; Jae Yeol Lee; Ji-Sun Shin; Kyung-Tae Lee; Nam-Suk Kang; Yeon Gyu Yu*. Identification of novel mPGES-1 inhibitors through screening of a chemical library. Bioorg. Med. Chem. Lett. 2012, 22(23), 7335-7339. 

  • Hong-Kun Rim, Heon-Woo Lee, Il Sook Choi, Jin Yeong Park, Heung Woo Choi, Jung-Hye Choi, Young-Wuk Cho, Jae Yeol Lee, Kyung-Tae Lee.* T-type Ca2+ channel blocker, KYS05047 induces G1 phase cell cycle arrest by decreasing intracellular Ca2+ levels in human lung adenocarcinoma A549 cells. Bioorg. Med. Chem. Lett. 2012, 22(23), 7123-7126.

  • Kwangkyu Lee, Yuna Jung, Jae Yeol Lee, Won-Kyu Lee, Dongbin Lim, Yeon Gyu Yu.* Purification and characterization of recombinant human endothelin receptor type A Protein Expression & Purification2012, 84(1), 14-18.

  • Ji-Sun Shin, Young-Su Noh, Min-Sang Yoo, Jae Yeol Lee, Young-Wuk Cho, Kyung-Tae Lee.* Anti-inflammatory and anti-arthritic effects of new synthetic 3-(4-hydroxyphenyl)-4-(4-thiomethoxyphenyl)-1H-pyrrole-2,5-dione. Bioorg. Med. Chem. Lett. 2012, 22(6), 2221–2225.

  • Seung-Jae Park, Ji-Sun Shin, Suran Ryu, Han Byul Kang, Tae Woo Kim, Jung-Hye Choi, Jae Yeol Lee, Young-Wuk Cho, Kyung-Tae Lee*. Potent anti-inflammatory effect of a novel furan-2,5-dione derivative, 3-(benzo[d]-1,3-dioxol-5-yl)-4-phenylfuran-2,5-dione, mediated by dual suppression of COX-2 activity and LPS-induced inflammatory gene expression via NF-kB inactivation. Brit. J. Pharmacol. 2012, 165(6), 1926-1940.

  • Tae Woo Kim, Byoung Wook Yoo, Joon Kwang Lee, Ji Han Kim, Kyung-Tae Lee, Yong Ha Chi*, Jae Yeol Lee*. Synthesis and Antihypertensive Activity of Pyrimidin-4(3H)-one Derivatives as Losartan Analogues for New Angiotensin II Receptor Type 1 (AT1) Antagonists. Bioorg. Med. Chem. Lett. 2012, 22(4), 1649–1654.

  • Han Byul Kang, Hong-Kun Rim, Ji-Hyung Seo, Kyung-Sook Chung, Jin Yeong Park, Heung Woo Choi, Doo Li Choi, Jungahn Kim, Dong Joon Choo, Kyung-Tae Lee, Jae Yeol Lee*, In vivo Evaluation of Oral Anti-tumoral Effect of 3,4-Dihydroquinazoline Derivative on Solid Tumor. Bioorg. Med. Chem. Lett. 2012, 22(2), 1198-1201.

  • Young Wook Son, Tae Hui Kwon, Jae Kyun Lee, Ae Nim Pae, Jae Yeol Lee, Yong Seo Cho,* and Sun-Joon Min*, A Concise Synthesis of Tetrabenazine: An Intramolecular Aza-Prins-type Cyclization via Oxidative C-H Activation. Org. Lett. 2011, 13(24), 6500-6503.

  • Bo-Bae Seo, Mi-Ran Park, ChangJu Chun, Jae Yeol Lee, Soo-Chang Song*,The biological efficiency and bioavailability of human growth hormone delivered using injectable, ionic, thermosensitive poly(organophosphazene)-polyethylenimine conjugate hydrogels. Biomaterials, 2011, 32(32), 8271-8280.

  • Hye-Eun Choi, Min-Sang Yoo, Jung-Hye Choi, Jae Yeol Lee, Je Hak Kim, Ji Han Kim,Joon Kwang Lee, Gyu Il Kim, Yong Park, Yong Ha Chi, Soo Heui Paik, Joo Han Lee,Kyung-Tae Lee BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endothelial cells, Bioorg. Med. Chem. Lett. 2011, 21(21), 6236-6241.

  • Eu-jin Cho, Ji-Sun Shin, Young-Su Noh, Young-Wuk Cho, Seung-Jae Hong, Jae-Hoon Park, Jae Yeol Lee, Jin-Yong Lee, Kyung-Tae Lee*. Anti-inflammatory effects of methanol extract of Patrinia scabiosaefolia in mice with ulcerative colitis. J. Ethnopharmacol. 2011, 136(3), 428-435.

  • Jong Taik Moon, Jin Ah Jung, Sung Hoon Ha, Sung Ho Song, Sung Jun Park, Jungahn Kim, Dong Joon Choo, Yong Sup Lee, Jae Yeol Lee*. Synthetic Studies on Erythrina Alkaloids: Formal Total Synthesis of (+)-3-Demethoxyerythratidinone. Synth. Commun. 2011, 41(9), 1282-1292.

  • Soo Yeon Jung, So Hyung Lee, Han Byul Kang, Hang Ah Park, Sun Ki Chang, Jungahn Kim, Dong Joon Choo, Chun Rim Oh, Young Deuk Kim, Ji Hyung Seo, Kyung-Tae Lee,  Jae Yeol Lee*. Antitumor Activity of 3,4-Dihydroquinazoline Dihydrochloride in A549 Xenograft Nude Mice. Bioorg. Med. Chem. Lett. 2010, 20(22), 6633-663.

  • Adrian Handforth,* Gregg E. Homanics, Douglas F. Covey, Kathiresan Krishnan, Jae Yeol Lee, Kenji Sakimura, Fredricka C. Martin, Arnulfo Quesada. T-Type Calcium Channel Antagonists Suppress Tremor in Two Mouse Models of Essential Tremor. Neuropharmacology 2010, 59(6), 380-387.

  • Kyeong Heon Kim, Jae Yeol Lee,* Tae Jin Park, Woo Sik Jeon,G.P.Kennedy, Jang Hyuk Kwon*. Small Molecule Host System for Solution-processed Red Phosphorescent OLEDs.  Synth. Met2010, 160(7-8), 631-635.

  • Jong Taik Moon, Ji Young Jeon, Hang Ah Park, Young-Soo Noh, Kyung-Tae Lee, Jungahn Kim, Dong Joon Choo,  Jae Yeol Lee*. Synthesis and Inhibition of PGE2 Productionof1H-Furan-2,5-dione and 1H-Pyrrole-2,5-dione Derivatives. Bioorg. Med. Chem. Lett. 2010, 20(2), 734-737.

  • Jong Taik Moon, Sung Hoon Ha, So Hyung Lee, Tae Hui Kwon, Chun Rim Oh, Young Deuk Kim, Jungahn Kim, Dong Joon Choo,  Jae Yeol Lee*. Total Synthesis and Biological Evaluation of Methylgerambullone. Bioorg. Med. Chem. Lett. 2010, 20(1), 52-55.

  • Jin Ah Jeong, Haelim Cho, SooYeon Jung, Han Byul Kang, Jin Yeong Park, Jungahn Kim, Dong Joon Choo,  Jae Yeol Lee*. 3D QSAR Studies on 3,4-Dihydroquinazolines as T-Type Calcium Channel Blocker by Comparative Molecular Similarity Indices Analysis (CoMSIA). Bioorg. Med. Chem. Lett. 2010, 20(1), 38-41.

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