Hyun-Ha Hwang, Jeong-Hui Je, Hyeong-Chan Lee, Ji-Sung Yoo, Jung Hwan Choi, Jin Won Hong, Hae-In Lim, Ga Yoon Kim, Yun-Beom Sim, Kwang-Jin Cho, Eun-wook Choi, Chunhoo Cheon, Jae Yeol Lee,*  Seong-Gyu Ko*. Sd-021, Decursin-Derivatives, Inhibits Tumorigenesis in NSCLC by Inhibiting the EGFR/STAT3 Signaling Pathway. Sci. Rep. 2025, 15, 22881.

Soo-Yeon Kim; Jae-Min Kim; Kyung-Sook Chung; Dae-sik Jang; Ja-Yeon Lee; Choi Kim; Jae Yeol Lee*; Kyung-Tae Lee* In vitro and in vivo anti-inflammatory effects of 5-hydroxyconiferaldehyde via NF-κB, MAPK/AP-1, and Nrf2 modulation. Chem Biol Interact. 2025. 409, 111427.

Mijin Jeon; Chang Hyeon Kong; Woo Chang Kang; Keontae Park; Min Seo Kim; Hoo Sik Min; Seo Yun Jung; Ho Jung Bae; Se Jin Park; Jae Yeol Lee; Ji Woon Kim; Jong Hoon Ryu. 4-Methoxycinnamic acid ameliorates post-traumatic stress disorder-like behavior in mice by antagonizing the CRF type 1 receptor. Life Sci.  2025. 361,123271. 

Kang, Heung Mo; Moon, Chang Sang; Nam, Yunchan; Lim, Jiwoong; Kim, Jiewan; Lee, Taehee; Lee, Junho; Chang, Mun Seog*; Lee, Jae Yeol*. Optimization and Scale-Up Synthesis of Lappaconitine Alkaloid Derivative, QG3030, as a Novel Osteoanabolic Agent. Org. Process Res. Dev. 2024. 28(12), 4328-4337.

Chang Sang Moon, Heung Mo Kang, Yunchan Nam, Jiwoong Lim, Jiewan Kim, Tae-Hee Lee, Junho Lee, Mun Seog Chang*, Jae Yeol Lee*, Structural Modification and Characteristics of Lappaconitine Alkaloid for the Discovery of Bioactive Components by Hypervalent Iodine Reagent, Org. Lett. 2024, 26(31), 6535-6539.

Junseong Ahn, Hyun-Ha Hwang, Soo Yeon Jung, Ja Yeon Lee, Choi Kim, Hye Min Choi, Min Ju Gwon, Min Ji Kim, Youngbin Kwon, Jaehyuk Woo, Bongkyu Park, Seong-Gyu Ko*, Jae Yeol Lee *, Synthesis, Antiproliferative Activity and Molecular Docking Analysis of Both Enantiomerically Pure Decursin Derivatives as Anticancer Agents. Chem. Pharm. Bull. 2024, 72(5), 498-506.

Min Ji Kim, Hwi-Ho Lee, Choi Kim, Ja Yeon Lee, Kyung-Sook Chung, Kyung-Tae Lee*, Jae Yeol Lee*, Selective mPGES-1 inhibitor ameliorated adjuvant-induced arthritis in rat model, J. Chem. 2024, 5531519.

You Bin Cho, Hyunbeom Lee, Hui-Jeon Jeon, Jae Yeol Lee*, Hyoung Ja Kim*, Antioxidant and inhibitory activities of Filipendula glaberrima leaf constituents against HMG-CoA reductase and macrophage foam cell formation, Molecules, 2024.29(2), 354.

Sang-Eun Park, Kyung-Sook Chung,So-Won Heo, Soo-Yeon Kim, Jeong-Hun Lee, Ahmed H.E. Hassan,Yong Sup Lee, Jae Yeol Lee, Kyung-Tae Lee, Therapeuticroleof2-stearoxyphenethylphosphocholinetargeting microtubule dynamics andWnt/β-catenin/EMTsignaling in human colorectal cancer cells, Life Sci. 2023, 334,122227.

Chang Hyeon Kong, Kyungnam Cho, Ji Won Min, Jae Youn Kim, Keontae Park, Do Yeon Kim, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Jae Yeol Lee, Jong Hoon Ryu, Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice, Biomed. Pharmacother. 2023, 168, 115639.

Gyeong Un Kim, Hyunmi Cho, Jae Kyun Lee, Jae Yeol Lee, Jinsung Tae, Sun-Joon Min*, Taek Kang*, Yong Seo Cho*, Stereoselective synthesis of 1,6-diazecanes by a tandem aza-Prins type dimerization and cyclization process ChemComm. 2023, 59(1), 82-85. 

Hyoung Ja Kim*, Jae Yeol Lee, Chunhoo Cheon, Seong-Gyu Ko, Development and validation of a new analytical HPLC-PDA method for simultaneous determination of cucurbitacins B and D from the roots of Trichosanthes kirilowii, J. Chem. 2022, 2109502.

Seyoung Yang, Eugene Huh, Gwang Hyun Moon, Junseong Ahn, Jiwon Woo, Hee-Soo Han, Hwi-HoLee, Kyung-Sook Chung, Kyung-Tae Lee*, Myung Sook Oh*, Jae Yeol Lee*. In vitro and in vivo neuroprotective effect of novel mPGES-1 inhibitor in animal model of Parkinson’s Disease. Bioorg. Med. Chem. Lett. 2022, 74, 128920.

Lexiao Li, Nelufar Yasmen, Ruida Hou, Seyoung Yang, Jae Yeol Lee, Jiukuan Hao, Ying Yu, Jianxiong Jiang*. Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke. Neurotherapeutics, 2022, 19(1), 366-385.

Junseong Ahn, Dohyeong Ko, Seyoung Yang, Kwang H. Moon, Jiwon Woo, Ho Yoo, Joohoon Ahn, Jeong H. Lee, Kyung S. Chung, Kyung-T. Lee*, and Jae Y. Lee*, Chiral resolution, absolute configuration assignment, and genotoxicity evaluation of racemic 3,4-dihydroquinazoline as a novel anti-cancer agent. J. Chem. 2021, 6169055.

Jeong-Hun Lee, Kyung-Sook Chung, Hwi-Ho Lee, Dohyeong Ko, Minji Kang, Ho Yoo , JooHoon Ahn, Jae Yeol Lee*, Kyung-Tae Lee*. Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells. Biomed. Pharmacother. 2021, 142, 111961.

Misong Kim , Geuntae Kim, Minji Kang, Dohyeong Ko, Yunchan Nam, Chang Sang Moon, Heung Mo Kang, Ji-Sun Shin, Oliver Werz, Kyung-Tae Lee *, Jae Yeol Lee *. Discovery of N-Amido-Phenylsulfonamide Derivatives as Novel Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors, Bioorg. Med. Chem. Lett. 2021, 41, 127992.

TaeHun Kim, Mohammad Neaz Morshed, Ashwini M. Londhe, Ji Woong Lim, Ha Eun Lee, Suengmok Cho, Sung Jin Cho, Hayoung Hwang, Sang Min Lim, Jae Yeol Lee, Jiyoun Lee, Ae Nim Pae. The Translocator Protein Ligands as Mitochondrial Functional Modulators for the Potential Anti-Alzheimer Agents, J. Enzyme Inhib. Med. Chem. 2021, 36(1), 831-846.

Yunchan Nam, Ki Deok Ryu, Changyoung Jang, Yoon Hyoung Moon, Misong Kim, Dohyeong Ko, Kyung-Sook Chung, Maria A. Gandini, Kyung-Tae Lee*, Gerald W. Zamponi*, Jae Yeol Lee*. Synthesis and Cytotoxic Effects of 2-Thio-3,4-dihydroquinazoline Derivatives as Novel T-Type Calcium Channel Blockers, Bioorg. Med. Chem. 2020, 28(11), 115491.

Jeong-Hun Lee, Hwi-Ho Lee, Ki Deok Ryu, Misong Kim, Dohyeong Ko, Kyung-Sook Chung, Ahmed H.E. Hassan, Seung Hyeun Lee, Jae Yeol Lee*, Kyung-Tae Lee*.  KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation. J. Clin. Med. 2020, 9(3), 704.

Jee Youn Lee, Hae Young Choi, Chan Sol Park, Changyoung Jang, Kyung-Tae Lee, Jae Yeol Lee, Inchan Youn, Tae Young Yune*. Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats, Int. Immunopharmacol. 2019, 75, 105738.

Hwi-Ho Lee, Yoon Hyoung Moon, Ji-Sun Shin, Jeong-Hun Lee, Tae-Woo Kim, Changyoung Jang, Changmin Park, Juhee Lee, Younghoon Kim, Younggwan Kim, Oliver Werz, Boyoung Y. Park, Jae Yeol Lee*, Kyung-Tae Lee*. A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models. Prostaglandins Other Lipid Mediat. 2019, 144, 106347.

Ha Eun Lee, Dami Lim, Jae Yeol Lee, Sang Min Lim**, Ae Nim Pae*. Recent tau-targeted clinical strategies for the treatment of Alzheimer's disease. Future Med. Chem. 2019, 11(15), 1845-1848.

Bo-Im Kim, Ju-Ha Kim, Deik Yong Sim, Minho Nam, Ji Hoon Jung, Bumsang Shim, Jae Yeol Lee, Sunghoon Kim*. Inhibition of JAK2/STAT3 and activation of caspase-9/3 are involved in KYS05090S-induced apoptosis in ovarian cancer cells. Int. J. Oncol. 2019, 55(1), 203-210.

Geon Chang Lee, Donghwa Seo, Junggyu Kim, Abu B. Siddique, Hyeonjong Park, Hyun Jun Kim, Ho-Jung Kang, Jae Yeol Lee, Jeewoo Lim,* Jungahn Kim,* Sehoon Kim. Cyclic Hydrazide-Functionalized Poly(ethylene oxide) Frameworks for the Synthesis of pH-Cleavable Drug-Carriers and Their Applications for the Stabilization of Gold Nanoparticles. Macromol. Chem. Phys. 2019, 220(10),1900075.

Ha Eun Lee, Dami Lim, Jae Yeol Lee, Sang Min Lim*, Ae Nim Pae*. Development of tau-directed small molecule modulators for Alzheimer’s disease: a recent patent review (2014-2018), Pharm. Pat. Anal. 2019, 8(1), 15-39.

Kyung-WonLee,Kyung-Sook Chung, Jeong-Hun Lee, Jung-Hye Choi, Sang Yoon Choi, Sanghee Kim, Jae Yeol Lee, Kyung-Tae Lee, Resveratrol analog, N-(4-methoxyphenyl)-3,5-dimethoxybenzamide induces G2/M phase cell cycle arrest and apoptosis in HeLa human cervical cancer cells. Food  Chem. Toxicol. 2019, 124, 101-111.

Hak Kyun Yang, Woo Seung Son, Keon Seung Lim, Gun Hee Kim, Eun Jeong Lim, Changdev G. Gadhe, Jae Yeol Lee, Kyu-Sung Jeong, Sang Min Lim,*  Ae Nim Pae*. Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain.  J. Enzyme Inhib. Med. Chem, 2018, 33(1), 1460-1471.

Ji Woong Lim, Seok Kyu Kim, Seo Yun Choi, Dong Hoi Kim, Changdev G, Gadhe, Hae-nim Lee, Hyo-Ji Kim, Jina Kim, Sung Jin Cho, Hayoung Hwang, Jihye Seong, Kyu-Sung Jeong, Jae Yeol Lee*, Sang Min Lim*, Jae Wook Lee*, Ae Nim Pae*. Identification of Crizotinib Derivatives as Potent SHIP2 Inhibitors for the Treatment of Alzheimer's Disease. Eur. J. Med. Chem. 2018, 157, 405-422.

Ambily Nath Indu Viswanath, Ji Woong Lim, Seon Hee Seo, Jae Yeol Lee, Sang Min Lim, Ae Nim Pae*.  GRP78-targeted in silico virtual screening of novel  anticancer  agents.  Chem. Biol. Drug. Des.  2018, 92(2), 1555-1566.

Sun Young Kim, Da Woon Jung, Hong Bin Yoon, Hwi-Ho Lee, Jeong-Hun Lee, Ji Sun Shin, Dami Lim, Hyoung Ja Kim, Ae Nim Pae, Jeong Ho Park, Jong Hoon Ryu, Kyung-Tae Lee,* Jae Yeol Lee.* A novel phenylsulfonamide ameliorates the cognitive impairment in mice induced by scopolamine. Bull. Korean Chem. Soc. 2018. 39(7), 891-894.

Hong Bin Yoon, Youra Lee, Donghwa Seo, Saeon Kim, Abu B. Siddique, Jae Yeol Lee, Jeewoo Lim, Jungahn Kim*. Michael addition of thiol compounds on ω-maleate poly(ethylene oxide)s: Model study for the "site-specific" modification of proteins. Macromol. Res. 2018, 26(2), 194-203.

Kwang Jong Kim, Gyeong Heon Kim, Raju Lampande, Dae Hyun Ahn, Joon Beom Im, Ji Su Moon, Jae Kyun Lee, Jae Yeol Lee*, Ju Young Lee*, Jang Hyuk Kwon*. A new rigid diindolocarbazole donor moiety for high quantum efficiency thermally activated delayed fluorescence emitter. J. Mater. Chem. C. 2018, 6, 1343-1348.

Bo-Bae Seo, Hae-Im Chang, Hyuck Choi, Jeong-Tae Koh, Kwi-Dug Yun, Jae Yeol Lee, Soo-Chang Song*. New approach for vertical bone regeneration using in situ gelling and sustained BMP-2 releasing poly (phosphazene) hydrogel system on peri-implant site with critical defect in a canine model. J. Biomed. Mater. Res. Part B.  2018, 106B, 751-759.

ra Jo, Hee-Soo Han, Seunghwan Seo, Ji-Sun Shin, Jae Yeol Lee, Hyoung Ja Kim*, Kyung Tae Lee*. Inhibitory effect of N-feruloylserotonin isolated from Carthamus tinctorius on LPS-induced inflammatory mediators via AP-1 and STAT1/3 inactivation in RAW 264.7 macrophages, Bioorg. Med. Chem. Lett. 2017, 27(23), 5245-5251.

Insun Park, Ashwini M. Londhe, Ji Woong Lim, Beoung-Geon Park, Seo Yun Jung, Jae Yeol Lee, Sang Min Lim, Kyoung Tai No, Jiyoun Lee, Ae Nim Pae*. Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction. J. Comput. Aided Mol. Des. 2017, 31(10), 929-941.

Ju-Ha Kim, Hee Young Kwon, Dong Hoon Ryu, Min-Ho Nam, Bum Sang Shim, Jin Han Kim, Jae Yeol Lee, Sung-Hoon Kim*. Inhibition of CUG-binding protein 1 and activation of caspases are critically involved in piperazine derivative BK10007S induced apoptosis in hepatocellular carcinoma cells. PLoS One 2017.12(10), e0186490.

Xu Kang, Jiange Qiu, Qianqian Li, Katherine Bell, Yifeng Du, Da Woon Jung,  Jae Yeol Lee, Jiukuan Hao, Jianxiong Jiang*. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci. Rep. 2017, 7(1), 9459.

Jin Han Kim, Hui Rak Jeong, Da Woon Jung, Hong Bin Yoon, Sun Young Kim, Hyoung Ja Kim, Kyung-Tae Lee*, Vinicius M. Gadotti, Junting Huang, Fang-Xiong Zhang, Gerald W. Zamponi*, Jae Yeol Lee*. Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects. Bioorg. Med. Chem. 2017, 25(17), 4656-4664.

Byeongyeon Park, Ji Hye Nam, Jin Han Kim, Hyoung Ja Kim, Valentina Onnis, Gianfranco Balboni*, Kyung-Tae Lee, Jeong Ho Park, Marco Catto, Angelo Carotti*, Jae Yeol Lee*. 3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes Bioorg. Med. Chem. Lett. 2017, 27(5), 1179-1185.

Abu B. Siddique, Jin Wook An, Hyun Jun Kim1, Hyeongjong Park, Young Jin Lee, Geon Chang Lee, Ho-Jung Kang, Jae Yeol Lee, Sehoon Kim, Jungahn Kim*. Synthesis of dual stimuli-responsive polymers through atom transfer radical mechanism in aqueous media. Macromol. Res. 2017, 25(1), 70-78.

Eun Beul Park, Kwang Jong Kim, Hui Rak Jeong, Jae Kyun Lee, Hyoung Ja Kim, Hwi Ho Lee, Ji Woong Lim, Ji-Sun Shin, Andreas Koeberle, Oliver Werz, Kyung-Tae Lee*, Jae Yeol Lee*. Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents. Bioorg. Med. Chem. Lett. 2016, 26(21), 5193-5197.

Seunghwan Seo, Kyoung-Goo Lee, Ji-Sun Shin, Eun Kyoung Chung, Jae Yeol Lee, Hyoung Ja Kim*, Kyung-Tae Lee*. 6´-O-Caffeoyldihydrosyringin isolated from Aster glehni suppresses lipopolysaccharide-induced iNOS, COX-2, TNF-α, IL-1β and IL-6 expression via NF-κB and AP-1 inactivation in RAW 264.7 macrophages. Bioorg. Med. Chem. Lett. 2016, 26(19), 4592-4598.

Ji Hoon Park, Eun Beul Park, Jae Yeol Lee, Ji-Young Min*. Identification of novel membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitors with anti-influenza activities in vitro. Biochem. Biophys. Res. Commun. 2016, 469(4), 848-855.

Sung Woo Kim, Abu Bakkar Siddique, Jin Wook An, Hyeon Jong Park, Hyun Jun Kim, Ho-Jung Kang, Jae Yeol Lee, Sehoon Kim, Jungahn Kim*. Quantitative ω-amination, ω-azidolysis, and ω-thiolation of poly(ethylene oxide)s through anionic mechanism. Macromol. Res. 2016, 24(2), 188-195.

Sa?d M’Dahoma, Vinicius M. Gadotti, Fang-Xiong Zhang, Byeongyeon Park, Ji Hye Nam, Valentina Onnis, Gianfranco Balboni*, Jae Yeol Lee*, Gerald W. Zamponi*. Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain. Pflugers Arch. - Eur. J. Physiol. 2016, 468(2), 193-199.

Joon Seok Byun, Joo Mi Sohn, Dong Gyu Leem, Byeongyeon Park, Ji Hye Nam, Dong Hyun Shin, Ji Sun Shin, Hyoung Ja Kim, Kyung-Tae Lee*, Jae Yeol Lee.* In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells. Bioorg. Med. Chem. Lett. 2016, 26(3), 1073-1079.

Sera Yang, Youn Kim, Hyeong Cheol Kim, Abu B. Siddique, Gyusaang Youn, Hyun Jun Kim, Hyeon Jong Park, Jae Yeol Lee, Sehoon Kim, Jungahn Kim*. Azide-based heterobifunctional poly(ethylene oxide)s: NaN3-initiated “living” polymerization of ethylene oxide and chain end functionalizations. Polym. Chem. 2016. 7. 394-401.

Minju Kim, Sunhoe Lee, Eun Beul Park, Kwang Jong Kim, Hwi Ho Lee, Ji-Sun Shin, Katrin Fischer, Andreas Koeberle, Oliver Werz* , Kyung-Tae Lee*, Jae Yeol Lee*.  Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study. Bioorg. Med. Chem. Lett. 2016, 26(1), 94-99.

Luciano De Petrocellis*, Aniello Schiano Moriello, Joon Seok Byun, Joo Mi Sohn, Jae Yeol Lee, Ana V?zquez-Romero, Maria Garrido, Angel Messeguer, Fang-Xiong Zhang, Gerald W. Zamponi, Alessandro Deplano, Cenzo Congiu, Valentina Onnis, Gianfranco Balboni*, Vincenzo Di Marzo*. Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel. Pharmacol. Res. 2015, 99, 362-369.

Jae Ho Jin, Eun Beul Park, Kwang Jong Kim, Minju Kim, Sunhoe Lee, Kyung-Tae Lee, Gyongseon Yang, Sooyoung Byun, Nakyung Lee, Junghyun Goo, Joo Hwan No, Dong Joon Choo*, Jae Yeol Lee* In Vitro Evaluation of s-Triazine Derivatives for African Trypanosomiasis. Bull. Korean Chem. Soc. 2015, 36(9), 2383-2386.

Min Jeoung Son, Changbae Jin, Yonh Sup Lee, Jae Yeol Lee, Hyoung Ja Kim* Characterization of Caffeoylglucoside Derivatives and Hypouricemic Activity of the Ethyl Acetate Fraction from Aster glehni. Bull. Korean Chem. Soc. 2015, 36(2), 503-512.

Sehyeon Cho, Min Ji Choi, Minju Kim, Sunhoe Lee, Jinsung Lee, Seok Joon Lee, Haelim Cho, Kyung-Tae Lee, Jae Yeol Lee* Three-dimensional Quantitative Structure-Activity Relationship Study on Anti-cancer Activity of 3,4-Dihydroquinazoline Derivatives Against Human Lung Cancer A549 Cells. J. Mol. Struct. 2015. 1084, 294-301.

Abu Bakkar Siddique, Youngjun Cho, Yujin Kim, Sung Hoon Bahng, Sung Woo Kim, Jae Yeol Lee, Ho-Jung Kang, Sehoon Kim, You Han Bae,  Jungahn Kim* pH-Sensitive Drug-Conjugates on Water-Soluble Polymer Frameworks  Macromol. Chem. Phys. 2015, 216(3), 265?276.

Seoung Mook Kang, Jinsung Lee, Jae Ho Jin, Minju Kim, Sunhoe Lee, Hwi Ho Lee, Ji-Sun Shin, Kyung-Tae Lee*, Jae Yeol Lee* Synthesis and PGE2 Production Inhibition of s-Triazine Derivatives as a Novel Scaffold in RAW 264.7 Macrophage Cells. Bioorg. Med. Chem. Lett. 2014, 24(23), 5418-5422.

Gi Hyun Kwon, Sehyeon Cho, Jinsung Lee, Joo Mi Sohn, Joon Seok Byun, Kyung-Tae Lee, Jae Yeol Lee* CoMSIA 3D-QSAR Analysis of 3,4-Dihydroquinazoline Derivatives Against Human Colon Cancer HT-29 Cells. Bull. Korean Chem. Soc. 2014, 35(11), 3181-3187.

Ji Eun Lee, Tae Hui Kwon, Su Jin Gu, Duck-Hyung Lee, B. Moon Kim, Jae Yeol Lee, Jae Kyun Lee, Seon Hee Seo, Ae Nim Pae, Gyochang Keum, Yong Seo Cho*, Sun-Joon Min.* Efficient synthesis of mibefradil analogues: an insight into in vitro stability. Org. Biomol. Chem. 2014, 12(30), 5669-5681.

Hong-Kun Rim, Sehyeon Cho, Dong-Hyun Shin, Kyung-Sook Chung, Young-Wuk Cho, Jung-Hye Choi, Jae Yeol Lee*, Kyung-Tae Lee.* T-Type Ca2+ Channel Blocker, KYS05090 Induces Autophagy and Apoptosis in A549 Cells through Inhibiting Glucose Uptake. Molecules 2014, 19(7), 9864-9875.

Seung-Hoon Bahng, Nan Hyun Kwon, Hyung Cheol Kim, Abu Bakkar Siddique, Ho-Jung Kang, Jae Yeol Lee, Joohoon Kim, Sehoon Kim, Jungahn Kim*. Simple synthesis of water-dispersible and photoactive titanium dioxide nanoparticles using functionalized poly(ethylene oxide)s. Macromol. Res. 2014, 22(4), 445-456.

Kyung Ju Kim, Min Ji Choi, Ji-Sun  Shin, Minju Kim, Hye-Eun Choi, Seoung Mook Kang, Jae Ho Jin, Kyung-Tae Lee,* Jae Yeol Lee.* Biological Evaluation, and Docking Analysis of a Novel Family of 1-Methyl-1H-pyrrole-2,5-diones as Highly Potent and Selective Cyclooxygenase-2 (COX-2) Inhibitors. Bioorg. Med. Chem. Lett. 2014, 24(8), 1958-1962.

Doo Li Choi, Sun Jeong Jang, Sehyeon Cho, Hye-Eun Choi, Hong-Kun Rim, Kyung-Tae Lee, Jae Yeol Lee.* Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist. Bioorg. Med. Chem. Lett. 2014, 24(6), 1565-1570.

Sun Jeong Jang, Heung Woo Choi, Doo Li Choi, Sehyeon Cho, Hong-Kun Rim, Hye-Eun Choi, Ki-Sun Kim, Minghua Huang, Hyewhon Rhim, Kyung-Tae Lee*, Jae Yeol Lee*. In Vitro Cytotoxicity on Human Ovarian Cancer Cells by T-Type Calcium Channel Blockers. Bioorg. Med. Chem. Lett. 2013, 23(14), 6656-6662.

Faisal Hayat, Sungjin Cho, Hyewhon Rhim, Ambily Nath Indu Vuswnath, Ae Nim Pae, Jae Yeol Lee, Dong Joon Choo, Hea-Young Park Choo*. Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group. Bioorg. Med. Chem. 2013, 21(17), 5573-5582.

Min Ji Choi, Gi Hyun Kwon, Nam Seok Han, Byoung Wook Yoo, Je Hak Kim, Soo Heui Paik, Yong Ha Chi, Jae Yeol Lee*. Development of 3D-QSAR CoMSIA Models for 5-(Biphenyl-2-yl)-1H-tetrazole Derivatives as Angiotensin II Receptor Type 1 (AT1) Antagonists. Bioorg. Med. Chem. Lett. 2013, 23(16), 4540-4546.

Yong Ha Chi, Joo Han Lee, Je Hak Kim, Hyun Kwang Tan, Sang Lin Kim, Jae Yeol Lee, Hong-Kun Rim, Soo Heui Paik*, Kyung-Tae Lee.* Pharmacological Characterization of BR-A-657, a Highly Potent Nonpeptide Angiotensin II Receptor Antagonist. Biol. Pharm. Bull. 2013, 36(7), 1208-1215.

Hye-Eun Choi, Jung-Hye Choi, Jae Yeol Lee, Je Hak Kim, Ji Han Kim, Joon Kwang Lee, Gyu Il Kim, Yong Park, Yong Ha Chi, Soo Heui Paik, Joo Han Lee, Kyung-Tae Lee.* Synthesis and evaluation of nicotinamide derivative as anti-angiogenic agents  Bioorg. Med. Chem. Lett. 2013, 23(7), 2083-2088.

Jin Yeong Park, Heung Woo Choi, Doo Li Choi, Sun Jeong Jang, Je Hak Kim, Joo Han Lee, Dong Joon Choo, Jungahn Kim, Kyung-Tae Lee, Jae Yeol Lee.*  Evaluation of T-Type Calcium Channel Blockers against Human Pancreatic MIA PaCa-2 Carcinoma Xenografts. Bull. Korean Chem. Soc. 2013, 34(2), 482-488 (Cover Article).

Kijae Lee, Van Chung Pham, Min Ji Choi, Kyung Ju Kim, Jungahn Kim, Dong Joon Choo, Kyung-Tae Lee, Yeon Gyu Yu, Jae Yeol Lee*. Fragment-Based Discovery of Novel and Selective mPGES-1 Inhibitors Part 1: Identification of Sulfonamido-1,2,3-Triazole-4,5-Dicarboxlic Acid. Bioorg. Med. Chem. Lett. 2013, 23(1), 75-80.

Joo Hyun Nam, Woo Seok Choi, Jae Hyeok Lee, Nan Hyun Kwon, Ho-Jung Kang, Jae Yeol Lee, Sehoon Kim, and Jungahn Kim.* Synthesis of Stimuli-Responsive PEO-Based Triblock Copolymers andTheir Applications for Preparation of Iron Oxide Nanoparticles. Macromol. Res. 2012, 20(11), 1173-1180.

Sung-Jun Park; Seong-Gu Han; Hafiz Muhammad Ahsan; Kijae Lee; Jae Yeol Lee; Ji-Sun Shin; Kyung-Tae Lee; Nam-Suk Kang; Yeon Gyu Yu*. Identification of novel mPGES-1 inhibitors through screening of a chemical library. Bioorg. Med. Chem. Lett. 2012, 22(23), 7335-7339.

Hong-Kun Rim, Heon-Woo Lee, Il Sook Choi, Jin Yeong Park, Heung Woo Choi, Jung-Hye Choi, Young-Wuk Cho, Jae Yeol Lee, Kyung-Tae Lee.* T-type Ca2+ channel blocker, KYS05047 induces G1 phase cell cycle arrest by decreasing intracellular Ca2+ levels in human lung adenocarcinoma A549 cells. Bioorg. Med. Chem. Lett. 2012, 22(23), 7123-7126.

Kwangkyu Lee, Yuna Jung, Jae Yeol Lee, Won-Kyu Lee, Dongbin Lim, Yeon Gyu Yu.* Purification and characterization of recombinant human endothelin receptor type A. Protein Expr. Purif. 2012, 84(1), 14-18.

Ji-Sun Shin, Young-Su Noh, Min-Sang Yoo, Jae Yeol Lee, Young-Wuk Cho, Kyung-Tae Lee.* Anti-inflammatory and anti-arthritic effects of new synthetic 3-(4-hydroxyphenyl)-4-(4-thiomethoxyphenyl)-1H-pyrrole-2,5-dione. Bioorg. Med. Chem. Lett. 2012, 22(6), 2221?2225.

Seung-Jae Park, Ji-Sun Shin, Suran Ryu, Han Byul Kang, Tae Woo Kim, Jung-Hye Choi, Jae Yeol Lee, Young-Wuk Cho, Kyung-Tae Lee*. Potent anti-inflammatory effect of a novel furan-2,5-dione derivative, 3-(benzo[d]-1,3-dioxol-5-yl)-4-phenylfuran-2,5-dione, mediated by dual suppression of COX-2 activity and LPS-induced inflammatory gene expression via NF-kB inactivation. Brit. J. Pharmacol. 2012, 165(6), 1926-1940.

Tae Woo Kim, Byoung Wook Yoo, Joon Kwang Lee, Ji Han Kim, Kyung-Tae Lee, Yong Ha Chi*, Jae Yeol Lee*. Synthesis and Antihypertensive Activity of Pyrimidin-4(3H)-one Derivatives as Losartan Analogues for New Angiotensin II Receptor Type 1 (AT1) Antagonists. Bioorg. Med. Chem. Lett. 2012, 22(4), 1649?1654.

Han Byul Kang, Hong-Kun Rim, Ji-Hyung Seo, Kyung-Sook Chung, Jin Yeong Park, Heung Woo Choi, Doo Li Choi, Jungahn Kim, Dong Joon Choo, Kyung-Tae Lee, Jae Yeol Lee*, In vivo Evaluation of Oral Anti-tumoral Effect of 3,4-Dihydroquinazoline Derivative on Solid Tumor. Bioorg. Med. Chem. Lett. 2012, 22(2), 1198-1201.

Young Wook Son, Tae Hui Kwon, Jae Kyun Lee, Ae Nim Pae, Jae Yeol Lee, Yong Seo Cho,* and Sun-Joon Min*, A Concise Synthesis of Tetrabenazine: An Intramolecular Aza-Prins-type Cyclization via Oxidative C-H Activation. Org. Lett. 2011, 13(24), 6500-6503.

Bo-Bae Seo, Mi-Ran Park, ChangJu Chun, Jae Yeol Lee, Soo-Chang Song*,The biological efficiency and bioavailability of human growth hormone delivered using injectable, ionic, thermosensitive poly(organophosphazene)-polyethylenimine conjugate hydrogels. Biomaterials, 2011, 32(32), 8271-8280.

Hye-Eun Choi, Min-Sang Yoo, Jung-Hye Choi, Jae Yeol Lee, Je Hak Kim, Ji Han Kim,Joon Kwang Lee, Gyu Il Kim, Yong Park, Yong Ha Chi, Soo Heui Paik, Joo Han Lee,Kyung-Tae Lee BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endothelial cells, Bioorg. Med. Chem. Lett. 2011, 21(21), 6236-6241.

Eu-jin Cho, Ji-Sun Shin, Young-Su Noh, Young-Wuk Cho, Seung-Jae Hong, Jae-Hoon Park, Jae Yeol Lee, Jin-Yong Lee, Kyung-Tae Lee*. Anti-inflammatory effects of methanol extract of Patrinia scabiosaefolia in mice with ulcerative colitis. J. Ethnopharmacol. 2011, 136(3), 428-435.

Jong Taik Moon, Jin Ah Jung, Sung Hoon Ha, Sung Ho Song, Sung Jun Park, Jungahn Kim, Dong Joon Choo, Yong Sup Lee, Jae Yeol Lee*. Synthetic Studies on Erythrina Alkaloids: Formal Total Synthesis of (+)-3-Demethoxyerythratidinone. Synth. Commun. 2011, 41(9), 1282-1292.

Soo Yeon Jung, So Hyung Lee, Han Byul Kang, Hang Ah Park, Sun Ki Chang, Jungahn Kim, Dong Joon Choo, Chun Rim Oh, Young Deuk Kim, Ji Hyung Seo, Kyung-Tae Lee, Jae Yeol Lee*. Antitumor Activity of 3,4-Dihydroquinazoline Dihydrochloride in A549 Xenograft Nude Mice. Bioorg. Med. Chem. Lett. 2010, 20(22), 6633-663.

Adrian Handforth,* Gregg E. Homanics, Douglas F. Covey, Kathiresan Krishnan, Jae Yeol Lee, Kenji Sakimura, Fredricka C. Martin, Arnulfo Quesada. T-Type Calcium Channel Antagonists Suppress Tremor in Two Mouse Models of Essential Tremor. Neuropharmacology 2010, 59(6), 380-387.

Kyeong Heon Kim, Jae Yeol Lee,* Tae Jin Park, Woo Sik Jeon, G.P. Kennedy, Jang Hyuk Kwon*. Small Molecule Host System for Solution-processed Red Phosphorescent OLEDs.  Synth. Met. 2010, 160(7-8), 631-635.

Jong Taik Moon, Ji Young Jeon, Hang Ah Park, Young-Soo Noh, Kyung-Tae Lee, Jungahn Kim, Dong Joon Choo, Jae Yeol Lee*. Synthesis and Inhibition of PGE2 Productionof1H-Furan-2,5-dione and 1H-Pyrrole-2,5-dione Derivatives. Bioorg. Med. Chem. Lett. 2010, 20(2), 734-737.

Jong Taik Moon, Sung Hoon Ha, So Hyung Lee, Tae Hui Kwon, Chun Rim Oh, Young Deuk Kim, Jungahn Kim, Dong Joon Choo, Jae Yeol Lee*. Total Synthesis and Biological Evaluation of Methylgerambullone. Bioorg. Med. Chem. Lett. 2010, 20(1), 52-55.

Jin Ah Jeong, Haelim Cho, SooYeon Jung, Han Byul Kang, Jin Yeong Park, Jungahn Kim, Dong Joon Choo, Jae Yeol Lee*. 3D QSAR Studies on 3,4-Dihydroquinazolines as T-Type Calcium Channel Blocker by Comparative Molecular Similarity Indices Analysis (CoMSIA). Bioorg. Med. Chem. Lett. 2010, 20(1), 38-41.